Cyclic Neutropenia

Cyclic Neutropenia

Cyclic neutropenia is an uncommon congenital blood disorder distinguish by abnormally low levels of certain white blood corpuscles (neutrophils) in the blood. It presents itself with frequent infections in the body like repetitive episodes of fever and mouth ulcers.


It occurs in one person in one million people in the world.

Cyclic Neutropenia is caused because of autosomal dominant innate mutations in ELA2 gene. This is the gene which encodes the gene neutrophils elastase. The gene is released when the body effort to fight in opposition to any infection in the body. But because of their absence, the bone marrow needs time to replenish the neutrophils supply. This neutrophils deficiency tends to occur every 3 weeks and lasts for 3 to 6 days.


The episodes of neutropenia become noticeable after birth. The cycle of neutropenia frequently comes after every 21 days lasting for 3 to 4 days.

Following symptoms might be follow after the cycle starts:-

  • Oral ulcers
  • Swelling and inflammation of gums (Gingivitis)
  • Recurrent fever
  • Generalized weakness and malaise
  • Sinusitis (Respiratory tract infections such as cough and cold)
  • Inflammation of throat (Pharyngitis)
  • Abdominal pain

Patients suffering from cyclic neutropenia have these symptoms only during the cycle. They remain asymptomatic otherwise. It is to be noted that the above listed symptoms may improve once the puberty sets in the child.


Patients with cyclic neutropenia should be genetically tested for ELANE gene.

Blood investigations like complete blood count, total leukocyte count and differential leukocyte count should be performed. The neutrophil count should be monitored twice in a month.

Homeopathic treatment

A sympathetic and supportive relief can be given to patients with cyclic neutropenia. Homeopathy can help out to boost the immunity and improve the general health of the patient. A good control can be achieved in the reappearance and frequency of the infectious attacks in the patients. The intensity of the symptoms plus time duration of the illness can be reduced which will improve the quality of life. Furthermore, oral and dental care is very important. Patients of chronic neutropenia should take care from trouble any major or minor injuries.

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